Opportunity Information: Apply for SFOP0005483

The FY19 Global Biosecurity Engagement Program Activities grant opportunity (SFOP0005483) is a U.S. Department of State funding announcement run by the Bureau of International Security and Nonproliferation, specifically through ISN/CTR, which manages the Biosecurity Engagement Program (BEP) within the broader Global Threat Reduction portfolio. It was posted on November 23, 2018, with an original application deadline of February 1, 2019. The assistance mechanism is a cooperative agreement, meaning awardees should expect close coordination with the U.S. government during planning, implementation, and oversight rather than operating with minimal federal involvement. The opportunity is categorized under “Other” as the funding activity type (with further clarification typically provided in the full announcement), and it is associated with CFDA 19.033. Eligibility is listed as “Unrestricted,” which generally signals openness to a wide range of applicant types, subject to any specific limitations or conditions described in the full notice.

The core purpose of the opportunity is national security-focused biosecurity and nonproliferation work. BEP’s mission is to reduce global biological threats by limiting access by terrorists or other malicious actors to the expertise, pathogens, materials, and specialized equipment that could enable biological attacks affecting the United States, its allies, or U.S. interests overseas. In practical terms, the program is designed to reduce opportunities for biological weapons or bioterrorism by strengthening how countries, institutions, and professionals manage dangerous biological risks. This includes both tangible security measures (protecting pathogens and facilities) and governance or compliance measures (aligning with international norms and legal frameworks).

The announcement highlights several main lines of effort that proposed projects are expected to support. One priority is preventing the illicit acquisition of weaponizable biological materials and related equipment by hostile actors, which can involve improving controls over access, handling, storage, and transfers, and strengthening institutional practices that reduce theft or diversion risks. Another priority is improving the ability to detect and disrupt potential bioterrorism plots, with emphasis on threats involving readily manufactured crude biological agents as well as agents that could cause mass casualties. The opportunity also emphasizes securing life science institutions and dangerous pathogens against both insider threats (such as disgruntled or compromised staff) and outsider threats (such as theft, intrusion, or coercion). In addition, it seeks to lower the risk that scientists or technical specialists with dual-use knowledge might intentionally misuse pathogens, which commonly connects to responsible conduct, risk awareness, and safeguards around sensitive research and capabilities.

A further major element is strengthening adherence to international biosecurity and nonproliferation frameworks that the United States supports. The announcement explicitly references advancing adoption of and compliance with United Nations Security Council Resolution 1540, the Biological and Toxin Weapons Convention (BWC), and the World Health Organization’s International Health Regulations, among other relevant frameworks. This signals that proposed activities may include helping partners build national systems, policies, and capacities that meet these obligations, such as improving regulatory approaches, national action planning, interagency coordination, reporting, and implementation practices that support durable compliance and measurable risk reduction.

In terms of scale, the award ceiling listed is $20,000,000, and the opportunity anticipates up to 15 awards. Taken together, the announcement describes a set of cooperative, security-oriented global health and biosafety/biosecurity activities aimed at preventing biological incidents and deliberate misuse, strengthening institutional and national safeguards, and supporting international norms that reduce the likelihood and potential impact of biological threats worldwide.

  • The Department of State, Bureau of International Security-Nonproliferation in the other (see text field entitled explanation of other category of funding activity for clarification) sector is offering a public funding opportunity titled "FY19 Global Biosecurity Engagement Program Activities" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 19.033.
  • This funding opportunity was created on Nov 23, 2018.
  • Applicants must submit their applications by Feb 01, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $20,000,000.00 in funding.
  • The number of recipients for this funding is limited to 15 candidate(s).
  • Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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