Opportunity Information: Apply for PA 19 125
The Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Required), opportunity number PA 19 125, is an NIH career development grant meant to pull experienced quantitative and engineering professionals into research areas that directly matter to human health and disease. The central idea is to support investigators who have strong training and productivity in fields like mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, or engineering, but whose prior work has not been mainly centered on biomedical or clinical questions. Through mentored training and research, the K25 is intended to help these investigators translate their quantitative expertise into NIH-relevant health research and build a long-term trajectory in that space.
A defining feature of this specific K25 announcement is that it is for applicants who will lead an independent clinical trial. That requirement is not optional here: the application is expected to include a plan where the candidate serves as the lead investigator on an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial that is separate and stands on its own. In other words, this FOA is designed for a candidate who is not merely joining someone else s trial to learn, but who is taking responsibility for designing and running their own clinical study as a key part of both the research plan and the career development plan. If an applicant does not intend to lead an independent clinical trial, or if they instead want experience working within a clinical trial that is led by another investigator, they are directed to apply to a companion FOA (listed as XXXXX in the provided text) rather than this one.
The award mechanism is structured around providing protected time for supervised study and research. That protected time is meant to give the candidate room to gain domain knowledge in biomedical or clinical areas, develop the necessary research and regulatory skills to conduct human subjects research, and integrate quantitative methods with real health and disease questions. Practically, this often means building competency in clinical research design, data collection in clinical settings, trial methodology, analysis strategies appropriate for clinical endpoints, and the broader scientific context needed to make quantitative innovations meaningful for patient care and public health. The mentored aspect is central: the program expects candidates to work under guidance while they transition into NIH-relevant research and establish independence.
Eligibility spans a wide range of organization types, reflecting NIH s broad funding ecosystem. Eligible applicants include various levels of government (state, county, city or township, and special district governments), independent school districts, and public housing authorities or Indian housing authorities. Higher education institutions are eligible across categories, including public and state controlled institutions, private institutions, and minority-serving or mission-focused institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs). Nonprofit organizations can apply whether or not they hold 501(c)(3) status, and both for-profit organizations (other than small businesses) and small businesses are listed as eligible as well. The FOA also notes faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions as eligible applicant types.
At the same time, the geographic eligibility rules are specific. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, are allowed. In practice, that means the applicant organization must be U.S.-based and eligible, but parts of the project may involve approved foreign components when justified and consistent with NIH policy.
This opportunity is categorized as a discretionary grant and falls under broad funding activity areas that include education and health, among others, consistent with career development and research training goals. The sponsoring agency is the National Institutes of Health, and the opportunity references multiple CFDA numbers (including 93.113, 93.121, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865, and 93.866), reflecting the many NIH institutes and centers that may participate or support awards under this parent mechanism. The record provided lists an original closing date of 2020-05-07 and a creation date of 2018-12-20; no award ceiling or expected number of awards is specified in the supplied source data.
Overall, PA 19 125 is best understood as a bridge for quantitatively trained professionals to become independent, NIH-relevant clinical researchers, with the added bar that the candidate must be prepared to take on leadership of an independent clinical trial (or a feasibility/ancillary trial) as an integral part of their mentored development plan.Apply for PA 19 125
- The National Institutes of Health in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865, 93.866.
- This funding opportunity was created on 2018-12-20.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Required) (PA 19 125)
What is the PA 19 125 K25 opportunity?
PA 19 125 is an NIH career development grant (Mentored Quantitative Research Development Award, Parent K25) intended to bring experienced quantitative and engineering professionals into research that directly relates to human health and disease. It supports mentored training and research so applicants can translate their quantitative expertise into NIH-relevant biomedical or clinical research and build a long-term trajectory in that space.
Who is this award designed for?
This award targets investigators who already have strong training and productivity in quantitative or engineering disciplines, but whose prior work has not been primarily focused on biomedical or clinical questions. The goal is to help them pivot into research areas that matter to health and disease through a structured, mentored career development path.
What fields or backgrounds does NIH consider a fit for this K25?
The opportunity explicitly points to backgrounds such as mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry, and engineering, among other quantitative fields. The common thread is demonstrated quantitative/engineering strength combined with a need to build deeper grounding in biomedical or clinical research.
What is the main purpose of the mentored component?
The mentored component is meant to provide supervised study and research time so the candidate can gain biomedical or clinical domain knowledge, develop clinical research and regulatory skills, and learn how to integrate quantitative methods with real health and disease questions. It is meant to support the transition into NIH-relevant research and progress toward independence.
Does PA 19 125 require a clinical trial?
Yes. A defining feature of this specific FOA is that it requires the applicant to lead an independent clinical trial. The clinical trial leadership requirement is not optional under PA 19 125.
What does "Independent Clinical Trial Required" mean in practice?
It means the application is expected to include a plan where the candidate serves as the lead investigator on an independent clinical trial, a clinical trial feasibility study, or an ancillary clinical trial that stands on its own. The FOA is designed for candidates who will take responsibility for designing and running their own clinical study as a key part of both the research plan and the career development plan.
Can I apply if I only plan to participate in someone else's clinical trial?
No, not under this FOA. If the applicant does not intend to lead an independent clinical trial, or only wants experience working within a clinical trial led by another investigator, the FOA text directs them to apply to a companion FOA (listed as XXXXX in the provided information) instead of PA 19 125.
What kinds of trials qualify under the independent clinical trial requirement?
Based on the provided information, the FOA expects the candidate to lead one of the following as an independent effort: (1) an independent clinical trial, (2) a clinical trial feasibility study, or (3) an ancillary clinical trial that is separate and stands on its own.
What does the award provide to help the candidate transition into health-related research?
The mechanism is structured around protected time for supervised study and research. That protected time is intended to create space for the candidate to build biomedical/clinical knowledge, learn human subjects research requirements, and develop the skills needed to design and conduct clinical research that is meaningful for patient care and public health.
What competencies or training areas are emphasized?
The opportunity highlights development in areas such as clinical research design, data collection in clinical settings, clinical trial methodology, analysis strategies appropriate for clinical endpoints, and the broader scientific and clinical context that makes quantitative innovation relevant to health and disease.
What is the role of quantitative methods in this award?
The program is specifically meant to help candidates translate existing quantitative expertise into NIH-relevant health research. The expectation is that quantitative and engineering methods are not just applied in isolation, but integrated with real clinical and biomedical questions so they can contribute to improved understanding of disease and better health outcomes.
What types of organizations are eligible to apply?
Eligibility includes a wide range of organizations, including multiple levels of government (state, county, city or township, and special district governments), independent school districts, and public housing authorities or Indian housing authorities. Higher education institutions are eligible (public/state controlled and private) as well as various minority-serving or mission-focused institutions.
Which minority-serving and mission-focused institutions are listed as eligible?
The FOA information includes eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs).
Are nonprofits eligible?
Yes. Nonprofit organizations are listed as eligible whether or not they have 501(c)(3) status.
Are for-profit organizations eligible?
Yes. The provided information lists for-profit organizations (other than small businesses) as eligible, and it also lists small businesses as eligible.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included among eligible applicant types in the provided information.
Are regional organizations or federal agencies eligible?
Yes. Regional organizations and eligible federal agencies are included among the listed eligible applicant types.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are included among the eligible applicant types in the provided information.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities and non-domestic foreign institutions are not eligible to apply under this opportunity.
Can a U.S. organization apply if parts of its organization are outside the U.S.?
The FOA states that non-domestic components of U.S. organizations are not eligible to apply. However, foreign components (as defined by the NIH Grants Policy Statement) are allowed, meaning parts of the project may include approved foreign components when justified and consistent with NIH policy, while the applicant organization itself must be U.S.-based and eligible.
What agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of funding is this considered?
It is categorized as a discretionary grant and is associated with broad funding activity areas including education and health, consistent with career development and research training goals.
What is the opportunity number and name?
The opportunity number is PA 19 125, and the name is Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Required).
What CFDA numbers are referenced for this opportunity?
The provided information references multiple CFDA numbers: 93.113, 93.121, 93.173, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865, and 93.866. This reflects that multiple NIH institutes and centers may participate or support awards under this parent mechanism.
When was this opportunity created, and what closing date is listed?
The record provided lists a creation date of 2018-12-20 and an original closing date of 2020-05-07.
Is there an award ceiling or an expected number of awards listed?
No. The supplied source data does not specify an award ceiling or the expected number of awards.
How should someone think about the overall goal of PA 19 125?
Overall, PA 19 125 is best understood as a bridge for quantitatively trained professionals to become independent, NIH-relevant clinical researchers, with the added requirement that the candidate must be prepared to lead an independent clinical trial (or a feasibility/ancillary trial) as an integral part of the mentored development plan.
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|---|
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) Apply for PA 19 119 Funding Number: PA 19 119 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) Apply for PA 19 118 Funding Number: PA 19 118 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Administrative Supplement for Research on Sex/Gender Influences (Admin Supp Clinical Trial Optional) Apply for PA 19 165 Funding Number: PA 19 165 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31) Apply for PA 19 195 Funding Number: PA 19 195 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (Parent F32) Apply for PA 19 188 Funding Number: PA 19 188 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions with NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 19 191 Funding Number: PA 19 191 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Fellowship for Students at Institutions Without NIH-Funded Institutional Predoctoral Dual-Degree Training Programs (Parent F30) Apply for PA 19 192 Funding Number: PA 19 192 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research on the Health of Women of Understudied, Underrepresented and Underreported (U3) Populations An ORWH FY19 Administrative Supplement (Admin Supp Clinical Trial Optional) Apply for PA 19 205 Funding Number: PA 19 205 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $140,000 |
| PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed Apply for PA 19 272 Funding Number: PA 19 272 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required Apply for PA 19 271 Funding Number: PA 19 271 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| PHS 2019-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed Apply for PA 19 270 Funding Number: PA 19 270 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Emergency Competitive Revision to Existing NIH Awards (Emergency Supplement - Clinical Trial Optional) Apply for PA 20 135 Funding Number: PA 20 135 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed) Apply for PA 20 166 Funding Number: PA 20 166 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required) Apply for PA 20 187 Funding Number: PA 20 187 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed) Apply for PA 20 185 Funding Number: PA 20 185 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Not Allowed) Apply for PA 20 188 Funding Number: PA 20 188 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required) Apply for PA 20 197 Funding Number: PA 20 197 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Support for Conferences and Scientific Meetings (Parent R13 Clinical Trial Not Allowed) Apply for PA 20 207 Funding Number: PA 20 207 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required) Apply for PA 20 206 Funding Number: PA 20 206 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Not Allowed) Apply for PA 20 205 Funding Number: PA 20 205 Agency: National Institutes of Health Category: Education, Environment, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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