Opportunity Information: Apply for RFA CA 17 004
The PDX Data Commons and Coordinating Center (PDCCC) opportunity (RFA-CA-17-004) is a National Cancer Institute (NCI) cooperative agreement (U24) designed to create a central hub for coordination, data management, and cross-network analysis for the Patient-Derived Xenograft Development and Trial Centers Research Network (PDXNet). PDXNet is an NCI program focused on accelerating cancer precision medicine by enabling large-scale, collaborative development of patient-derived xenograft (PDX) models and using those models to run standardized preclinical studies of targeted cancer therapies. In practical terms, the PDCCC is meant to be the backbone of the network, making it possible for multiple PDX centers to generate comparable data, share resources, and jointly interpret results in a way that is bigger than what any single site could accomplish.
The FOA positions PDXNet as a coordinated network made up of four PDX Development and Trial Centers (PDTCs), which are supported under a companion announcement (RFA-CA-17-003). Those PDTCs are expected to build new PDX models, improve and standardize methods for preclinical testing, and evaluate both single drugs and drug combinations. They will also leverage existing, well-characterized PDX models to study drug response patterns. The PDCCC is specifically intended to connect these activities across sites by serving as the coordinating and data analysis center. That implies responsibilities like organizing network-wide workflows, harmonizing data elements and assay metadata, supporting consistent quality practices, and enabling network-level comparisons and integrated analyses so that results from different centers can be interpreted together rather than as isolated studies.
A major motivation emphasized in the description is translational impact: the network is expected to produce results that help prioritize which drug combinations should move forward for further development. In particular, the FOA highlights the relevance to NCI Investigational New Drugs (NCI-IND agents) and the Experimental Therapeutic Clinical Trials Network (ETCTN). The intent is that rigorous, coordinated PDX-based preclinical evidence can inform which therapeutic combinations look most promising for clinical evaluation, helping to focus clinical trial resources on combinations supported by stronger model-based rationale.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, National Institutes of Health, using a cooperative agreement mechanism, which typically indicates substantial programmatic involvement from NIH/NCI staff in shaping milestones, coordination expectations, and network governance. The activity area is listed under education and health, and the CFDA numbers associated with the opportunity are 93.394 and 93.395. The announcement was created on December 6, 2016, with an original closing date of March 3, 2017, and it anticipated a single award with an annual budget ceiling of $650,000. That single-award structure reinforces that the PDCCC is meant to be a unified, network-wide resource rather than one of several parallel coordinating centers.
Eligibility is broad and includes many types of organizations that could credibly run a national-scale data commons and coordinating function. Eligible applicants include federal recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofit organizations with and without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, independent school districts, special districts, and public housing authorities/Indian housing authorities, with additional eligibility details referenced in the full FOA text. Overall, the opportunity is centered on building the shared infrastructure and operational coordination needed for PDXNet to generate standardized, high-value preclinical datasets and analyses that can directly inform precision oncology drug development decisions.Apply for RFA CA 17 004
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "PDX Data Commons and Coordinating Center (PDCCC) for the PDX Development and Trial Centers Research Network (PDXNet) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on Dec 06, 2016.
- Applicants must submit their applications by Mar 03, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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FAQs: PDX Data Commons and Coordinating Center (PDCCC) Opportunity (RFA-CA-17-004)
1) What is the PDCCC funding opportunity (RFA-CA-17-004)?
The PDX Data Commons and Coordinating Center (PDCCC) opportunity (RFA-CA-17-004) is a National Cancer Institute (NCI) cooperative agreement (U24) intended to establish a central hub for coordination, data management, and cross-network analysis for the Patient-Derived Xenograft Development and Trial Centers Research Network (PDXNet).
2) Which agency is offering this opportunity?
This is a discretionary funding opportunity from the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), specifically the National Cancer Institute (NCI).
3) What funding mechanism is used for this award?
The award uses a cooperative agreement mechanism (U24). This typically indicates substantial programmatic involvement from NIH/NCI staff in shaping milestones, coordination expectations, and network governance.
4) What is PDXNet and what is its purpose?
PDXNet is an NCI program focused on accelerating cancer precision medicine by enabling large-scale, collaborative development of patient-derived xenograft (PDX) models and using those models to run standardized preclinical studies of targeted cancer therapies.
5) What role does the PDCCC play within PDXNet?
The PDCCC is intended to serve as the backbone of PDXNet by enabling coordination across sites, supporting shared data management, and making cross-network comparisons and integrated analyses possible so results from different centers can be interpreted together rather than as isolated studies.
6) How is the PDXNet network structured under this FOA?
The FOA describes PDXNet as a coordinated network made up of four PDX Development and Trial Centers (PDTCs) supported under a companion announcement (RFA-CA-17-003), plus the PDCCC, which serves as the coordinating and data analysis center connecting the PDTC activities.
7) What is the companion announcement mentioned, and how does it relate to this one?
The companion announcement is RFA-CA-17-003, which supports the four PDX Development and Trial Centers (PDTCs). Those centers focus on building and testing PDX models, while the PDCCC (this opportunity, RFA-CA-17-004) is designed to coordinate and integrate data and analysis across the network.
8) What are PDTCs expected to do (as described here)?
PDTCs are expected to build new PDX models, improve and standardize methods for preclinical testing, evaluate single drugs and drug combinations, and leverage existing well-characterized PDX models to study patterns of drug response.
9) What kinds of activities are implied for the PDCCC?
Based on the description, the PDCCC is expected to organize network-wide workflows, harmonize data elements and assay metadata, support consistent quality practices, and enable network-level comparisons and integrated analyses across participating centers.
10) Why is standardization across sites emphasized?
Standardization is emphasized so that multiple PDX centers can generate comparable data and share resources, enabling network-level interpretation and integrated analysis that is larger in scope and impact than what any single site could accomplish alone.
11) What is meant by “cross-network analysis” in this context?
In this context, cross-network analysis refers to analyses that combine or compare data generated across multiple PDTC sites so that results can be interpreted together, supporting broader conclusions than site-by-site analyses.
12) What translational outcome is a major motivation for this program?
A major motivation highlighted is translational impact: producing results that help prioritize which drug combinations should move forward for further development, using rigorous, coordinated PDX-based preclinical evidence.
13) How does the FOA connect PDCCC/PDXNet work to NCI-IND agents and ETCTN?
The description highlights relevance to NCI Investigational New Drugs (NCI-IND agents) and the Experimental Therapeutic Clinical Trials Network (ETCTN). The intent is that coordinated preclinical evidence can help identify therapeutic combinations that appear most promising for clinical evaluation, helping focus clinical trial resources on combinations supported by stronger model-based rationale.
14) How many awards were anticipated?
The opportunity anticipated a single award, reinforcing that the PDCCC is meant to be a unified, network-wide resource rather than multiple parallel coordinating centers.
15) What was the annual budget ceiling for the anticipated award?
The anticipated annual budget ceiling was $650,000.
16) What is the activity area listed for this opportunity?
The activity area is listed under education and health.
17) What CFDA numbers are associated with this opportunity?
The CFDA numbers associated with the opportunity are 93.394 and 93.395.
18) When was the announcement created and what was the original closing date?
The announcement was created on December 6, 2016, and the original closing date was March 3, 2017.
19) Who is eligible to apply?
Eligibility is broad. Eligible applicants include: federally recognized tribal governments and tribal organizations; state and local governments; public and private institutions of higher education; nonprofit organizations with and without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; independent school districts; special districts; and public housing authorities/Indian housing authorities. Additional eligibility details are referenced in the full FOA text.
20) Is this opportunity limited to academic institutions?
No. The listed eligibility includes a wide range of organization types, including academic institutions, nonprofits, for-profits (with the noted exception), small businesses, multiple government entities, and other public organizations.
21) What does “data commons” imply for the PDCCC based on the description?
Based on the description, “data commons” implies shared infrastructure for data management across the network, including harmonization of data elements and assay metadata, and the ability to perform coordinated, network-level analyses using standardized datasets.
22) What is the practical value of having a single PDCCC for the network?
The practical value described is having one unified backbone to coordinate workflows, align data practices, and support integrated analysis, making it easier for results from different sites to be comparable and interpreted together.
23) What kinds of study outputs is the network aiming to inform?
The network is expected to generate coordinated preclinical findings intended to help prioritize targeted therapy combinations for further development and potential clinical evaluation.
24) Where are additional eligibility details found?
The description indicates that additional eligibility details are referenced in the full FOA text.
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| Canine Immunotherapy Trials and Correlative Studies (U01) Apply for RFA CA 17 001 Funding Number: RFA CA 17 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
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