Opportunity Information: Apply for RFA CA 17 004
The PDX Data Commons and Coordinating Center (PDCCC) opportunity (RFA-CA-17-004) is a National Cancer Institute (NCI) cooperative agreement (U24) designed to create a central hub for coordination, data management, and cross-network analysis for the Patient-Derived Xenograft Development and Trial Centers Research Network (PDXNet). PDXNet is an NCI program focused on accelerating cancer precision medicine by enabling large-scale, collaborative development of patient-derived xenograft (PDX) models and using those models to run standardized preclinical studies of targeted cancer therapies. In practical terms, the PDCCC is meant to be the backbone of the network, making it possible for multiple PDX centers to generate comparable data, share resources, and jointly interpret results in a way that is bigger than what any single site could accomplish.
The FOA positions PDXNet as a coordinated network made up of four PDX Development and Trial Centers (PDTCs), which are supported under a companion announcement (RFA-CA-17-003). Those PDTCs are expected to build new PDX models, improve and standardize methods for preclinical testing, and evaluate both single drugs and drug combinations. They will also leverage existing, well-characterized PDX models to study drug response patterns. The PDCCC is specifically intended to connect these activities across sites by serving as the coordinating and data analysis center. That implies responsibilities like organizing network-wide workflows, harmonizing data elements and assay metadata, supporting consistent quality practices, and enabling network-level comparisons and integrated analyses so that results from different centers can be interpreted together rather than as isolated studies.
A major motivation emphasized in the description is translational impact: the network is expected to produce results that help prioritize which drug combinations should move forward for further development. In particular, the FOA highlights the relevance to NCI Investigational New Drugs (NCI-IND agents) and the Experimental Therapeutic Clinical Trials Network (ETCTN). The intent is that rigorous, coordinated PDX-based preclinical evidence can inform which therapeutic combinations look most promising for clinical evaluation, helping to focus clinical trial resources on combinations supported by stronger model-based rationale.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, National Institutes of Health, using a cooperative agreement mechanism, which typically indicates substantial programmatic involvement from NIH/NCI staff in shaping milestones, coordination expectations, and network governance. The activity area is listed under education and health, and the CFDA numbers associated with the opportunity are 93.394 and 93.395. The announcement was created on December 6, 2016, with an original closing date of March 3, 2017, and it anticipated a single award with an annual budget ceiling of $650,000. That single-award structure reinforces that the PDCCC is meant to be a unified, network-wide resource rather than one of several parallel coordinating centers.
Eligibility is broad and includes many types of organizations that could credibly run a national-scale data commons and coordinating function. Eligible applicants include federal recognized tribal governments and tribal organizations, state and local governments, public and private institutions of higher education, nonprofit organizations with and without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, independent school districts, special districts, and public housing authorities/Indian housing authorities, with additional eligibility details referenced in the full FOA text. Overall, the opportunity is centered on building the shared infrastructure and operational coordination needed for PDXNet to generate standardized, high-value preclinical datasets and analyses that can directly inform precision oncology drug development decisions.Apply for RFA CA 17 004
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "PDX Data Commons and Coordinating Center (PDCCC) for the PDX Development and Trial Centers Research Network (PDXNet) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394, 93.395.
- This funding opportunity was created on Dec 06, 2016.
- Applicants must submit their applications by Mar 03, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $650,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Applicants who have applied for this opportunity (RFA CA 17 004) also looked into and applied for these:
| Funding Opportunity |
|---|
| PDX Development and Trial Centers (PDTCs) (U54) Apply for RFA CA 17 003 Funding Number: RFA CA 17 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $800,000 |
| Mechanisms of Cancer Drug Resistance and Sensitivity (U54) Apply for RFA CA 17 009 Funding Number: RFA CA 17 009 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Consortium for Pancreatic Ductal Adenocarcinoma (PDAC) Translational Studies on the Tumor Microenvironment (U01) Apply for RFA CA 17 015 Funding Number: RFA CA 17 015 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Resource Center for the Consortium for Pancreatic Ductal Adenocarcinoma (PDAC) Translational Studies (U24) Apply for RFA CA 17 016 Funding Number: RFA CA 17 016 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Coordinating Center for Canine Immunotherapy Trials and Correlative Studies (U24) Apply for RFA CA 17 002 Funding Number: RFA CA 17 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Canine Immunotherapy Trials and Correlative Studies (U01) Apply for RFA CA 17 001 Funding Number: RFA CA 17 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Administrative Supplements to Promote Research Collaborations on Fusion Oncoproteins as Drivers of Childhood Cancer (Admin Supp) Apply for PA 17 138 Funding Number: PA 17 138 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $135,000 |
| Data Management and Coordinating Center (DMCC) for the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Collaborative Research Centers (CRC) (U24) Apply for RFA NS 17 022 Funding Number: RFA NS 17 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| NIDA Translational Avant-Garde Award for Development of Medication to Treat Substance Use Disorders (UG3/UH3) Apply for RFA DA 18 003 Funding Number: RFA DA 18 003 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Intensive Longitudinal Analysis of Health Behaviors: Leveraging New Technologies to Understand Health Behaviors (U01) Apply for RFA OD 17 004 Funding Number: RFA OD 17 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Intensive Longitudinal Analysis of Health Behaviors: Leveraging New Technologies to Understand Health Behaviors (U24) Apply for RFA OD 17 005 Funding Number: RFA OD 17 005 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Integration and Validation of Emerging Technologies to Accelerate Cancer Research (R33) Apply for RFA CA 17 023 Funding Number: RFA CA 17 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $325,000 |
| Limited Competition: Palliative Care Research Cooperative (PCRC) (U2C) Apply for RFA NR 17 001 Funding Number: RFA NR 17 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| SBIR Phase II Bridge Awards to Accelerate the Development of Cancer Therapeutics, Imaging Technologies, Interventional Devices, Diagnostics, and Prognostics toward Commercialization (R44) Apply for RFA CA 17 024 Funding Number: RFA CA 17 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,000,000 |
| Pediatric Early Phase Clinical Trials Network (UM1) Apply for RFA CA 17 027 Funding Number: RFA CA 17 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,600,000 |
| Limited Competition: A Data Resource for Analyzing Blood and Marrow Transplants (U24) Apply for RFA CA 17 031 Funding Number: RFA CA 17 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $2,875,000 |
| Consortium on Translational Research in Early Detection of Liver Cancer (Clinical and Research Centers (U01) Apply for RFA CA 17 025 Funding Number: RFA CA 17 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| Coordinating Center for the Consortium of Translational Research in Early Detection of Liver Cancer (U24) Apply for RFA CA 17 028 Funding Number: RFA CA 17 028 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Minority-Patient Derived Xenograft (PDX) Development and Trial Center (PDTC) Network (U54) Apply for RFA CA 17 032 Funding Number: RFA CA 17 032 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $800,000 |
| Research Centers for Improving Management of Symptoms Across Cancer Treatments (IMPACT) (UM1) Apply for RFA CA 17 042 Funding Number: RFA CA 17 042 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $1,120,000 |
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