Opportunity Information: Apply for RFA AG 19 002

The Small Research Grant Program for the Next Generation of Clinical Researchers in Alzheimer's Disease (AD) and Alzheimer's Disease Related Dementias (ADRD) Research (R03 Clinical Trial Optional), funding opportunity number RFA-AG-19-002, is a National Institutes of Health (NIH) discretionary grant designed to support early, important, and innovative research projects that address gaps in scientific knowledge related to Alzheimer's disease, related dementias, and healthy brain aging. The main purpose of the program is to encourage and help develop the next generation of U.S.-based clinical and neuroscience researchers by giving them resources to launch or strengthen a research trajectory in AD/ADRD, including work that can improve prevention strategies, diagnostic approaches, treatments, and the quality of care.

This opportunity uses the NIH R03 mechanism, which is typically intended for smaller, focused projects that can be completed with limited resources and within a shorter period compared to larger research grants. The announcement is explicitly labeled "Clinical Trial Optional," meaning applicants may propose studies that include clinical trials, but they are not required to do so. In practice, this allows the program to support a broad range of research designs, from early-stage clinical or translational studies to methods development and other innovative approaches that can quickly produce useful data or proof-of-concept findings in AD/ADRD.

Funding falls under the NIH health research activity category, with CFDA numbers 93.853 and 93.866. The listed award ceiling is $100,000, indicating that proposals are expected to fit within a modest budget appropriate for a small research grant. The notice shows an original closing date of July 3, 2018, and a creation date of April 25, 2018, which reflects the specific published cycle for this particular announcement.

Eligibility is broad and includes many types of U.S. organizations and government entities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; nonprofits both with and without 501(c)(3) IRS status (as long as they are not institutions of higher education, since those are listed separately); for-profit organizations other than small businesses; and small businesses. The program also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. This emphasis signals an interest in reaching a wide range of institutions, including those that serve historically underrepresented communities, consistent with the goal of expanding and strengthening the future AD/ADRD research workforce.

At the same time, the opportunity places clear restrictions on foreign involvement. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, and non-domestic components of U.S. organizations are also not eligible. In addition, foreign components, as defined in the NIH Grants Policy Statement, are not allowed. In other words, the applicant organization and the project components supported by this award must be domestic, reinforcing the program's stated focus on building the next generation of researchers in the United States.

Overall, this grant opportunity is best understood as a targeted, early-career-friendly funding mechanism meant to spark new lines of AD/ADRD clinical and neuroscience research, generate preliminary data, and help investigators establish themselves in the field. It prioritizes innovative, needed investigations that can move the science forward in practical areas like prevention, diagnosis, treatment, and care, while using a small-grant structure to enable quicker, focused progress and career development for emerging researchers.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Small Research Grant Program for the Next Generation of Clinical Researchers in Alzheimer's Disease (AD) and Alzheimers Disease Related Dementias (ADRD) Research (R03 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
  • This funding opportunity was created on 2018-04-25.
  • Applicants must submit their applications by 2018-07-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $100,000.00 in funding.
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for RFA AG 19 002

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