Opportunity Information: Apply for RFA OH 24 004
The World Trade Center (WTC) Health Program Mentored Research Scientist Career Development Award (K01) is a federal grant opportunity run through the Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), and specifically the National Institute for Occupational Safety and Health (NIOSH) in partnership with the WTC Health Program. Its core goal is to build the next generation of independent investigators focused on health conditions affecting people exposed to the September 11 attacks. The award is designed as a bridge between postdoctoral or early research training and later-stage independent research support such as U01 or R01 level funding, helping promising early-career scientists establish themselves in WTC-related health research.
A central feature of this K01 is the requirement for substantial "protected time" for career development. The program provides support for 75 percent protected research time for up to three years, allowing an awardee to focus intensively on a mentored research and training plan rather than being pulled primarily into clinical, teaching, or administrative duties. The expectation is that the applicant will work under close supervision from an experienced mentor (or mentoring team) and use the award period to strengthen research skills, produce publishable findings, and lay the groundwork for an independent research trajectory centered on WTC health priorities.
The research focus is explicitly tied to diagnostic or treatment uncertainty for conditions affecting people covered under Subtitle B of the James Zadroga 9/11 Health and Compensation Act of 2010 (as amended). In practice, that means applications are expected to identify real-world gaps where clinicians, patients, and health systems face uncertainty about how best to diagnose, monitor, treat, prevent, or manage health outcomes in this population. Applicants must clearly explain what uncertainty they are addressing, why it matters, and how the proposed work will reduce ambiguity and improve decision-making. The application also needs to make a compelling case for why the candidate needs mentored support at this stage and how the award will meaningfully accelerate their transition to research independence.
The intended beneficiaries of the research are the 9/11-exposed communities served by the WTC Health Program: WTC responders, screening-eligible WTC survivors, and certified-eligible WTC survivors. A notable aspect of the announcement is that the funded research is primarily meant to benefit these groups specifically, and it is not required that findings be broadly generalizable to other populations. This makes the program especially suited to projects that are deeply tailored to the exposures, clinical profiles, healthcare delivery context, and long-term needs of the WTC population.
NIOSH is inviting mentored clinical research projects across six broad areas of interest: translation research (moving evidence into practice), health services research (how care is organized, delivered, accessed, and paid for), health equity research (addressing disparities and fairness in outcomes and access), treatment research (evaluating interventions and care strategies), prevention research (reducing risk or progression of illness), and quality of life research (patient-centered functioning and well-being). Applicants are expected to articulate not only what they will do during the project period, but also the anticipated impacts after the award ends, such as follow-on studies, scalable care improvements, or a sustained independent research program.
In terms of administrative details, this is a discretionary grant opportunity with the funding opportunity number RFA OH 24 004 and CFDA number 93.262. It was posted in September 2023 with an application deadline in early December 2023 (with electronic submissions due by 5:00 pm ET on the listed due date). The listing indicated an expectation of around 10 awards. The eligible applicant organizations are broad and include federal-eligible research performers across government, academia, nonprofit organizations, and for-profit entities (including small businesses), with the specific caveat that eligibility follows the categories listed and any clarifications provided in the full announcement.
Finally, applicants are encouraged to make use of the WTC Health Program research resources, which include a research agenda, publication library, and tools such as a funding dashboard that shows previously awarded projects, topics, populations studied, funding levels, and investigator and institutional information. These resources are meant to help applicants align proposed projects with program priorities, understand what has already been funded, and identify where unanswered questions remain.Apply for RFA OH 24 004
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "World Trade Center Health Program Mentored Research Scientist Career Development Award (K01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.262.
- This funding opportunity was created on Sep 07, 2023.
- Applicants must submit their applications by Dec 05, 2023 Electronically submitted applications must be submitted no later than 500 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the WTC Health Program Mentored Research Scientist Career Development Award (K01)?
The WTC Health Program Mentored Research Scientist Career Development Award (K01) is a federal grant opportunity administered within the U.S. Department of Health and Human Services (HHS) through the Centers for Disease Control and Prevention (CDC), specifically the National Institute for Occupational Safety and Health (NIOSH), in partnership with the WTC Health Program. It is intended to develop the next generation of independent investigators focused on health conditions affecting people exposed to the September 11 attacks.
What is the main purpose of this K01 award?
The core purpose is to serve as a bridge between postdoctoral or early research training and later-stage independent research support (such as U01 or R01 funding). The program is designed to help promising early-career scientists establish themselves and build a durable, independent research trajectory centered on WTC-related health priorities.
Which federal agencies and programs are involved in this opportunity?
This opportunity is run through HHS and CDC, with NIOSH as the specific CDC institute leading the effort, in partnership with the WTC Health Program.
What does "mentored" mean in the context of this award?
The award expects the applicant to conduct a structured mentored research and training plan under close supervision from an experienced mentor (or a mentoring team). The mentored period is intended to strengthen research skills, produce publishable results, and position the candidate to become an independent investigator in WTC health research.
How much protected time does the K01 provide?
The program provides support for 75 percent protected research time, allowing the awardee to focus intensively on career development and mentored research rather than primarily on clinical, teaching, or administrative duties.
How long can the award support an applicant?
The opportunity provides protected time and support for up to three years.
What kind of research is this K01 meant to support?
The K01 is oriented toward mentored clinical research that addresses diagnostic or treatment uncertainty for health conditions affecting people covered under Subtitle B of the James Zadroga 9/11 Health and Compensation Act of 2010 (as amended). Applications are expected to identify real-world gaps where uncertainty affects how clinicians, patients, or health systems diagnose, monitor, treat, prevent, or manage health outcomes in the WTC population.
What does the opportunity mean by "diagnostic or treatment uncertainty"?
It refers to areas where there is ambiguity or lack of clarity in the best approach to diagnosis, monitoring, treatment, prevention, or management for WTC-related health conditions. Applicants are expected to clearly explain what uncertainty they are addressing, why it matters, and how the proposed project will reduce that ambiguity and improve decision-making.
Who is the research intended to benefit?
The intended beneficiaries are 9/11-exposed communities served by the WTC Health Program, including WTC responders, screening-eligible WTC survivors, and certified-eligible WTC survivors.
Do funded findings need to be broadly generalizable to other populations?
No. The announcement notes that the research is primarily meant to benefit the WTC Health Program populations specifically, and it is not required that findings be broadly generalizable to other populations. This makes the opportunity well-suited to projects tailored to the exposures, clinical profiles, healthcare delivery context, and long-term needs of the WTC population.
What broad research areas does NIOSH encourage for this K01?
NIOSH invites mentored clinical research projects across six broad areas of interest: translation research, health services research, health equity research, treatment research, prevention research, and quality of life research.
What is translation research in this context?
Translation research focuses on moving evidence into practice, supporting efforts that help ensure research findings are adopted and used in real-world clinical or program settings relevant to WTC Health Program populations.
What is health services research in this context?
Health services research focuses on how care is organized, delivered, accessed, and paid for, with emphasis on improving healthcare delivery and decision-making for WTC Health Program populations.
What is health equity research in this context?
Health equity research focuses on disparities and fairness in outcomes and access, aiming to address inequities affecting WTC responders and survivors served by the WTC Health Program.
What is treatment research in this context?
Treatment research evaluates interventions and care strategies relevant to WTC-related health conditions, with the goal of reducing uncertainty and improving clinical decisions for the covered populations.
What is prevention research in this context?
Prevention research focuses on reducing risk or progression of illness in the WTC population, targeting strategies that can prevent onset or worsening of health outcomes tied to 9/11 exposures.
What is quality of life research in this context?
Quality of life research emphasizes patient-centered functioning and well-being, supporting projects that aim to improve day-to-day outcomes and longer-term well-being for WTC responders and survivors.
What must an application explain about the problem it is addressing?
Applications must clearly describe the specific diagnostic or treatment uncertainty being targeted, why it matters for WTC populations, and how the proposed work will reduce ambiguity and improve clinical or health system decision-making.
What must an application explain about the candidate's career stage?
The application needs to make a compelling case for why the candidate needs mentored support at this stage and how the award will meaningfully accelerate the transition to independent research focused on WTC health priorities.
Is the award intended to lead to additional funding after the K01 period?
Yes. The K01 is described as a bridge toward later-stage independent research support such as U01 or R01 funding. Applicants are also expected to articulate anticipated impacts after the award ends, such as follow-on studies, scalable care improvements, or a sustained independent research program.
What is the funding opportunity number and CFDA number for this grant?
The funding opportunity number is RFA OH 24 004, and the CFDA number is 93.262.
What type of grant opportunity is this?
This is described as a discretionary grant opportunity.
When was this opportunity posted and when was the deadline?
The listing was posted in September 2023, with an application deadline in early December 2023. Electronic submissions were due by 5:00 pm ET on the listed due date.
How many awards were expected?
The listing indicated an expectation of around 10 awards.
Which organizations are eligible to apply?
Eligible applicant organizations are broad and include federal-eligible research performers across government, academia, nonprofit organizations, and for-profit entities (including small businesses). Eligibility follows the categories listed and any clarifications provided in the full announcement.
What WTC Health Program resources are applicants encouraged to use?
Applicants are encouraged to use WTC Health Program research resources such as the research agenda, publication library, and tools including a funding dashboard.
What information can the WTC Health Program funding dashboard provide?
The funding dashboard is described as showing previously awarded projects, topics, populations studied, funding levels, and investigator and institutional information. These details can help applicants align proposed work with program priorities and identify what questions remain unanswered.
How can the research agenda and publication library help an applicant?
These resources are intended to help applicants align proposed projects with program priorities, understand what has already been funded or published, and identify gaps where diagnostic or treatment uncertainty remains for WTC Health Program populations.
What makes this opportunity distinct from more general health research grants?
A key distinction is that the funded research is primarily meant to benefit WTC Health Program populations (responders and eligible survivors), and broad generalizability to other populations is not required. The focus is also tightly tied to reducing diagnostic or treatment uncertainty for WTC-covered conditions under the Zadroga Act (Subtitle B).
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