Opportunity Information: Apply for CDC RFA DD19 1903
Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies (CDC RFA DD19 1903) is a CDC cooperative agreement focused on improving how therapeutic red blood cell transfusions are used and managed for people living with thalassemia and sickle cell disease. The opportunity recognizes that transfusions are a central therapy for many patients, but the need for transfusion varies widely, ranging from none at all to chronic transfusions every few weeks. Because transfusions can be life-preserving yet carry real risks, the program is aimed at clarifying who benefits most, when transfusions should start, how frequently they should occur, and what practical steps reduce transfusion-related complications so patient outcomes improve over time.
A major driver behind this funding is the persistent gap in identifying thalassemia in the United States. Unlike conditions that are universally screened for, thalassemia is not consistently included in newborn screening panels nationwide, meaning many individuals and even their health care providers may not realize they have thalassemia until symptoms become obvious or complications develop. This delay can push transfusion initiation later than ideal, and in some cases the diagnosis may never be made, leaving patients without the potential benefits of appropriate transfusion therapy and related supportive care. The CDC is using this opportunity to strengthen identification and awareness so patients can be recognized earlier and connected to informed, consistent clinical management.
The grant also emphasizes reducing complications associated with transfusion therapy, which include iron overload, alloimmunization, and infectious risks. Iron chelation therapy is highlighted as a necessary companion treatment for transfused patients once iron measures exceed threshold levels, reflecting the reality that repeated transfusions can lead to harmful iron accumulation if not monitored and treated. Alloimmunization is another key complication, occurring when a patient develops antibodies after exposure to red blood cell antigens that differ from their own, potentially making future transfusions more difficult and dangerous. Frequent transfusions also increase exposure to pathogens that can be transmitted through blood, underscoring the importance of safety practices, monitoring, and data-driven transfusion protocols.
To address these issues, the NOFO lays out a multi-part approach that goes beyond traditional clinical research alone and leans into systems improvement and public health infrastructure. Funded recipients are expected to (1) identify patients, families, communities, and providers who would benefit from more knowledge about therapeutic transfusions and their complications; (2) develop and disseminate educational and clinical materials that improve understanding of diagnosis and management for thalassemia and sickle cell disease; and (3) collect biological specimens from individuals with these conditions. The intent is that better-informed communities and providers, paired with more standardized information and specimen resources, will support more consistent transfusion decision-making and complication prevention across settings.
This opportunity explicitly builds on lessons from prior CDC work under CDC-RFA-DD14-1406. Those findings pointed to several persistent challenges the new awards are meant to tackle: the difficulty of identifying thalassemia patients and their providers before complications arise (except in states where newborn screening includes the condition), inconsistent transfusion practices across and even within clinical sites and blood banks, the need to spread evidence-based or consensus-based transfusion guidelines more widely, and the opportunity to increase blood donation among communities most affected by thalassemia and sickle cell disease. In practice, that means projects are expected to help close the gap between what is known as best practice and what is happening day to day in diverse health care systems.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, Centers for Disease Control and Prevention (NCBDDD), offered as a cooperative agreement, which typically means CDC will have substantial involvement and collaboration with awardees during the project period. Eligible applicants are broad and include various levels of government, public and private institutions of higher education, tribal governments and organizations, nonprofits with or without 501(c)(3) status, and for-profit entities including small businesses. The posted award ceiling is $375,000, with an expectation of two awards. The opportunity was originally posted February 26, 2019, with an original closing date of May 3, 2019, and required electronic submission by 11:59 p.m. ET on the due date.
Overall, the NOFO is aimed at practical, real-world improvement in transfusion-related care for hemoglobinopathies: finding people earlier, helping clinicians and blood banks align around more standardized and safer transfusion practices, educating the communities most impacted, and creating supporting resources like educational tools and biological specimen collections. The intended outcomes are reduced transfusion-related complications, better continuity and coordination of care, improved quality of life, and longer life for individuals with thalassemia or sickle cell disease.Apply for CDC RFA DD19 1903
- The Department of Health and Human Services, Centers for Disease Control - NCBDDD in the health sector is offering a public funding opportunity titled "Characterizing the Complications Associated with Therapeutic Blood Transfusions for Hemoglobinopathies" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.080.
- This funding opportunity was created on Feb 26, 2019.
- Applicants must submit their applications by May 03, 2019 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $375,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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