Opportunity Information: Apply for RFA AG 20 043
The grant opportunity titled "SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging (U24 Clinical Trials Not Allowed)" (Funding Opportunity Number RFA AG 20 043) is a National Institutes of Health program administered through the Department of Health and Human Services, specifically aligned with the National Institute on Aging's priorities in Alzheimer's disease and related dementias (ADRD). It uses the cooperative agreement mechanism (U24), which typically means the NIH expects to have substantial involvement in shaping the project during the award period, rather than simply funding an independently run project. The overarching goal is to build and operate a single, centralized infrastructure that can bring together neuroimaging data generated across the network of NIA-supported Alzheimer's Disease Research Centers (ADRCs), and then make that data more usable and more broadly accessible by harmonizing, managing, and sharing it in a standardized way.
At its core, SCAN is about solving a common, high-impact problem in large research consortia: imaging data are expensive to collect and extremely valuable, but they often end up scattered across sites, stored in different formats, described with inconsistent metadata, and processed using different pipelines. Those differences make it hard to combine datasets, compare results, or run analyses at scale. This opportunity supports the creation of a centralized resource that can aggregate both existing ("legacy") neuroimaging datasets already collected at ADRCs and future datasets generated moving forward. The emphasis on harmonization signals that the award is meant to do more than simple data warehousing; it is intended to support systematic standardization across sites so researchers can reliably pool data, track provenance, and interpret variables consistently. In practical terms, this type of infrastructure would be expected to address common pain points such as differences in scan protocols, file structures, naming conventions, clinical and demographic annotations, and analytic processing methods, while also ensuring that data can be shared in ways that are compliant with human-subjects protections and data governance expectations.
The award is categorized under Health and is associated with CFDA number 93.866, reflecting its placement within NIH's broader research support portfolio. The notice explicitly states "Clinical Trials Not Allowed," which indicates that the funded activities should not involve conducting clinical trials. Instead, the work should focus on infrastructure, data coordination, curation, standard-setting, and enabling secondary analysis and broad reuse of imaging data collected through ADRCs. In other words, SCAN is designed to be a backbone resource for the community: it is meant to make ADRC neuroimaging data findable, usable, and shareable at scale, thereby increasing the scientific return on investments already made in imaging studies and accelerating progress in understanding Alzheimer's disease and related dementias.
In terms of who can apply, eligibility is broad and includes many types of domestic organizations: various levels of government (state, county, city or township, and special districts), independent school districts, public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories), federally recognized tribal governments and certain tribal organizations, public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), small businesses, and other entities as allowed under the additional eligibility text referenced in the listing. This broad eligibility aligns with the infrastructure nature of the project, since data coordination and platform-building can be housed in universities, research institutes, nonprofits, or specialized organizations with the technical capacity to run large-scale data systems.
The funding parameters indicate a single expected award, with an award ceiling of $1,000,000. That combination (one award, sizable ceiling, cooperative agreement mechanism) reflects an intent to create a centralized national resource rather than multiple parallel efforts. The opportunity was created on May 22, 2019, with an original closing date of July 22, 2019, placing it within a defined application window typical of NIH RFAs that target a specific programmatic need. Overall, SCAN is best understood as an enabling grant: it is designed to strengthen the research ecosystem by building shared neuroimaging infrastructure for ADRD, improving data consistency and accessibility, and ultimately making it easier for investigators to conduct rigorous, large-scale, multi-site analyses using ADRC neuroimaging data.Apply for RFA AG 20 043
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "SCAN: Standardized Centralized Alzheimer's and Related Dementias Neuroimaging (U24 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on May 22, 2019.
- Applicants must submit their applications by Jul 22, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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